Polymorphism of the human MUC genes

被引：48

作者：

Fowler, J ^{[1
]}

Vinall, L ^{[1
]}

Swallow, D ^{[1
]}

机构：

[1] Dept Biol, Galton Lab, London NW1 2HE, England

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2001年 / 6卷

关键词：

mucin; polymorphism; glycoprotein; review;

D O I：

10.2741/Fowler

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mucins encoded by the MUC genes share the common feature of having an extensive tandem repeat region that encompasses a large proportion of the coding sequence. In many of the genes this tandem repeat region shows a great deal of allelic length variation and recently studies have demonstrated person to person variation in pattern of nucleotide or amino-acid changes in the repeat units. The length and sequence variability will be discussed in this review, as will its role in disease susceptibility.

引用

收藏

页码：D1207 / D1215

页数：9

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