Is niacin ineffective? Or did AIM-HIGH miss its target?

被引：32

作者：

Nicholls, Stephen J. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Cleveland Clin, Dept Cardiovasc Med, Lerner Coll Med, Cleveland, OH 44195 USA

[2] Cleveland Clin, Cleveland Clin Coordinating Ctr Clin Res, Inst Heart & Vasc, Cleveland, OH USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2012年 / 79卷 / 01期

关键词：

HIGH-DENSITY-LIPOPROTEIN; EXTENDED-RELEASE NIACIN; CORONARY-HEART-DISEASE; HDL CHOLESTEROL; NICOTINIC-ACID; HIGH-RISK; SIMVASTATIN; COMBINATION; ATHEROSCLEROSIS; PREVENTION;

D O I：

10.3949/ccjm.79a.11166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) found, in an interim analysis, no cardiovascular benefit from taking extended-release niacin (Niaspan). In fact, there was a trend toward a greater risk of ischemic stroke, which did not reach statistical significance. But questions remain about this complex trial, which included intensive statin therapy in the active-treatment group and the control group.

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页码：38 / 43

页数：6

相关论文

共 18 条

[1] Effects of torcetrapib in patients at high risk for coronary events [J].

Barter, Philip J. ;

Caulfield, Mark ;

Eriksson, Mats ;

Grundy, Scott M. ;

Kastelein, John J. P. ;

Komajda, Michel ;

Lopez-Sendon, Jose ;

Mosca, Lori ;

Tardif, Jean-Claude ;

Waters, David D. ;

Shear, Charles L. ;

Revkin, James H. ;

Buhr, Kevin A. ;

Fisher, Marian R. ;

Tall, Alan R. ;

Brewer, Bryan .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (21) :2109-2122

[2] Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy [J].

Boden, William E. ;

Probstfield, Jeffrey L. ;

Anderson, Todd ;

Chaitman, Bernard R. ;

Desvignes-Nickens, Patrice ;

Koprowicz, Kent ;

McBride, Ruth ;

Teo, Koon ;

Weintraub, William .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (24) :2255-2267

[3] Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk [J].

Brown, B. Greg ;

Zhao, Xue-Qiao .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 101 (8A) :58B-62B

[4] Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease [J].

Brown, BG ;

Zhao, XQ ;

Chait, A ;

Fisher, LD ;

Cheung, MC ;

Morse, JS ;

Dowdy, AA ;

Marino, EK ;

Bolson, EL ;

Alaupovic, P ;

Frohlich, J ;

Albers, JJ ;

Serafini, L ;

Huss-Frechette, E ;

Wang, S ;

DeAngelis, D ;

Dodek, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (22) :1583-1592

[5] 15 YEAR MORTALITY IN CORONARY DRUG PROJECT PATIENTS - LONG-TERM BENEFIT WITH NIACIN [J].

CANNER, PL ;

BERGE, KG ;

WENGER, NK ;

STAMLER, J ;

FRIEDMAN, L ;

PRINEAS, RJ ;

FRIEDEWALD, W .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1986, 8 (06) :1245-1255

[6]

Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3

[7] Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol [J].

deLemos, AS ;

Wolfe, ML ;

Long, CJ ;

Sivapackianathan, R ;

Rader, DJ .

CIRCULATION, 2002, 106 (11) :1321-1326

[8]

Ginsberg HN, 2010, NEW ENGL J MED, V362, P1563, DOI 10.1056/NEJMoa1001282

[9] HIGH-DENSITY LIPOPROTEIN AS A PROTECTIVE FACTOR AGAINST CORONARY HEART-DISEASE - FRAMINGHAM STUDY [J].

GORDON, T ;

CASTELLI, WP ;

HJORTLAND, MC ;

KANNEL, WB ;

DAWBER, TR .

AMERICAN JOURNAL OF MEDICINE, 1977, 62 (05) :707-714

[10] RAISING HDL CHOLESTEROL WITH LOW-DOSE NICOTINIC-ACID AND BEZAFIBRATE - PRELIMINARY EXPERIENCE [J].

LURIA, MH ;

SAPOZNIKOV, D .

POSTGRADUATE MEDICAL JOURNAL, 1993, 69 (810) :296-299