Deposition of aqueous aerosol of technetium-99m diethylene triamine penta-acetic acid generated and delivered by a novel system (AERx) in healthy subjects

被引:28
作者
Chan, HK [1 ]
Daviskas, E
Eberl, S
Robinson, M
Bautovich, G
Young, I
机构
[1] Univ Sydney, Dept Pharm, Sydney, NSW 2006, Australia
[2] Royal Prince Alfred Hosp, Dept Resp, Sydney, NSW, Australia
[3] Royal Prince Alfred Hosp, Dept PET, Sydney, NSW, Australia
[4] Royal Prince Alfred Hosp, Dept Nucl Med, Sydney, NSW, Australia
关键词
radioaerosol; lung deposition; drug delivery; ventilation imaging; technetium-99m diethylene triamine penta-acetic acid;
D O I
10.1007/s002590050393
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Deposition of technetium-99m diethylene triamine penta-acetic acid aqueous radioaerosols generated by a novel aerosol delivery system (AER(x)) was studied in six healthy subjects using both planar and single-photon emission tomography (SPET) imaging. AER(x) is a microprocessor-controlled. bolus inhalation device that is actuated at pre-programmed values of inspiratory flow rate and volume. The aims of the study were to determine the effects of posture and inhaled volume upon deposition of the aerosol in the lungs. Each subject inhaled the radioaerosol in two positions (supine vs sitting) and with two inspiratory manoeuvres [vital capacity (VC) vs "fixed volume" of 11 above functional residual capacity]. Simultaneous transmission-emission planar and tomographic images were acquired. The results showed diffuse deposition of the aerosol in the lung. Neither the breathing manoeuvre nor the posture was found to affect the distribution of the aerosol as measured by the ratio of the activity (counts per pixel) in the peripheral:central (penetration index, PI) or in the apex:base regions of the planar lung images (P>0.1). A small, albeit statistically significant, difference in PI (P<0.03) was found between VC and fixed volume sitting manoeuvres with SPET only. The PI values themselves indicate that the radioaerosol was well distributed in the lung, with the periphery having 45%-64% of the activity of the central region. Superposition of transmission SPET lung outline on emission SPET visually confirmed the excellent peripheral deposition of the aerosol. The AER(x) system showed high efficiency of delivery, with approximately 50% of the extruded dose in the device depositing in the lung. The uniformity of radioactivity distributed throughout the lung is attributed to the fine particle size (mass median aerodynamic diameter of 2 mu m) of the aerosol and the electronic control of aerosol inhalation by the device. In conclusion, the AER(x) system can be ideal for Jiff use aerosol deposition of therapeutic or diagnostic agents and is largely unaffected by inhaled volume and posture. The efficiency of the device device can limit the total radiation exposure of patients and staff administering the radioaerosols, and can make it suitable for delivery of expensive drugs.
引用
收藏
页码:320 / 327
页数:8
相关论文
共 14 条
[1]  
BAILEY DL, 1989, J NUCL MED, V30, P1865
[2]   REGIONAL DEPOSITION OF NEBULIZED HYPODENSE NONISOTONIC SOLUTIONS IN THE HUMAN RESPIRATORY-TRACT [J].
CHAN, HK ;
PHIPPS, PR ;
GONDA, I ;
COOK, P ;
FULTON, R ;
YOUNG, I ;
BAUTOVICH, G .
EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (08) :1483-1489
[3]  
Eberl S, 1996, J NUCL MED, V37, P137
[4]   CRANIO-CAUDAL DISTRIBUTION OF INSPIRED GAS AND PERFUSION IN SUPINE MAN [J].
ENGEL, LA ;
PREFAUT, C .
RESPIRATION PHYSIOLOGY, 1981, 45 (01) :43-53
[5]  
FARR SJ, 1996, RESPIRATORY DRUG DEL, V5, P175
[6]  
FARR SJ, 1998, RESP DRUG DELIVERY, V6, P25
[7]  
MACEY DJ, 1982, J NUCL MED, V23, P731
[8]  
MEIKLE SR, 1994, J NUCL MED, V35, P360
[9]  
NEWMAN SP, 1993, AEROSOLS MED PRINCIP, P375
[10]  
PELTIER P, 1992, EUR J NUCL MED, V19, P349