Pharmacokinetically guided dosing of carboplatin and etoposide during peritoneal dialysis and haemodialysis

被引：31

作者：

English, MW ^{[1
]}

Lowis, SP ^{[1
]}

Peng, B ^{[1
]}

Boddy, A ^{[1
]}

Newell, DR ^{[1
]}

Price, L ^{[1
]}

Pearson, ADJ ^{[1
]}

机构：

[1] ROYAL VICTORIA INFIRM,SCH MED,CANC RES UNIT,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1996年 / 73卷 / 06期

关键词：

carboplatin; etoposide; Wilms' tumour; haemodialysis; peritoneal dialysis;

D O I：

10.1038/bjc.1996.135

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two patients with relapsed Wilms' tumour and renal failure requiring dialysis were given carboplatin and etoposide by pharmacokinetically guided dosing. The target area under the drug plasma concentration vs time curve (AUG) was 6 mg ml(-1) min for carboplatin and 18 and 21 mg ml(-1) min for etoposide. On course 1 measured AUCs of carboplatin and etoposide were 6 and 20 mg ml(-1) min for patient 1 and 6 and 21 mg ml(-1) min for patient 2 respectively. Peritoneal dialysis did not remove carboplatin or etoposide from the plasma, however carboplatin but not etoposide was cleared by haemodialysis. Therapy with carboplatin and etoposide is possible in children and adults with renal failure who require dialysis, but in this situation pharmacokinetic monitoring is essential.

引用

页码：776 / 780

页数：5

共 31 条

[1] CARBOPLATIN DOSAGE - PROSPECTIVE EVALUATION OF A SIMPLE FORMULA BASED ON RENAL-FUNCTION [J].

CALVERT, AH ;

NEWELL, DR ;

GUMBRELL, LA ;

OREILLY, S ;

BURNELL, M ;

BOXALL, FE ;

SIDDIK, ZH ;

JUDSON, IR ;

GORE, ME ;

WILTSHAW, E .

JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (11) :1748-1756

[2] PHARMACOKINETICS OF CARBOPLATIN IN A PATIENT SUFFERING FROM ADVANCED OVARIAN-CARCINOMA WITH HEMODIALYSIS-DEPENDENT RENAL INSUFFICIENCY [J].

CHATELUT, E ;

ROSTAING, L ;

GUALANO, V ;

VISSAC, T ;

DEFORNI, M ;

TONTHAT, H ;

SUC, JM ;

HOUIN, G ;

CANAL, P .

NEPHRON, 1994, 66 (02) :157-161

[3]

CLARK PI, 1988, P AM ASSOC CANC RES, V29, P192

[4] PROGRAM PACKAGE FOR SIMULATION AND PARAMETER-ESTIMATION IN PHARMACOKINETIC SYSTEMS [J].

DARGENIO, DZ ;

SCHUMITZKY, A .

COMPUTER PROGRAMS IN BIOMEDICINE, 1979, 9 (02) :115-134

[5] PHASE-II STUDY OF CARBOPLATIN AS A SINGLE DRUG FOR RELAPSED WILMS-TUMOR - EXPERIENCE OF THE BRAZILIAN WILMS-TUMOR STUDY-GROUP [J].

DECAMARGO, B ;

MELARAGNO, R ;

SILVA, NSE ;

MENDONCA, N ;

ALVARES, MN ;

MORINAKA, E ;

MARQUES, A ;

CUSATO, MP .

MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 22 (04) :258-260

[6]

DINCALCI M, 1986, CANCER RES, V46, P2566

[7]

ETTINGER LJ, 1994, CANCER, V73, P1297, DOI 10.1002/1097-0142(19940215)73:4<1297::AID-CNCR2820730427>3.0.CO

[8]

2-#

[9]

FOX JG, 1991, CANCER, V68, P1720, DOI 10.1002/1097-0142(19911015)68:8<1720::AID-CNCR2820680812>3.0.CO

[10]

2-A

← 1 2 3 4 →