Effects of selective attention on the electrophysiological representation of concurrent sounds in the human auditory cortex

被引:168
作者
Bidet-Caulet, Aurelie
Fischer, Catherine
Besle, Julien
Aguera, Pierre-Emmanuel
Giard, Marie-Helene
Bertrand, Olivier
机构
[1] Ctr Hosp Vinatier, INSERM, Unite 821, F-69500 Bron, France
[2] Neurol Hosp, Inst Fed Neurosci, F-69000 Lyon, France
[3] Univ Lyon 1, Neurol Hosp, F-69000 Lyon, France
[4] Neurol Hosp, Dept Funct Neurol & Epileptol, F-69000 Lyon, France
关键词
auditory cortex; attention; intracranial EEG; human; event-related; steady-state; concurrent sound;
D O I
10.1523/JNEUROSCI.1402-07.2007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In noisy environments, we use auditory selective attention to actively ignore distracting sounds and select relevant information, as during a cocktail party to follow one particular conversation. The present electrophysiological study aims at deciphering the spatiotemporal organization of the effect of selective attention on the representation of concurrent sounds in the human auditory cortex. Sound onset asynchrony was manipulated to induce the segregation of two concurrent auditory streams. Each stream consisted of amplitude modulated tones at different carrier and modulation frequencies. Electrophysiological recordings were performed in epileptic patients with pharmacologically resistant partial epilepsy, implanted with depth electrodes in the temporal cortex. Patients were presented with the stimuli while they either performed an auditory distracting task or actively selected one of the two concurrent streams. Selective attention was found to affect steady-state responses in the primary auditory cortex, and transient and sustained evoked responses in secondary auditory areas. The results provide new insights on the neural mechanisms of auditory selective attention: stream selection during sound rivalry would be facilitated not only by enhancing the neural representation of relevant sounds, but also by reducing the representation of irrelevant information in the auditory cortex. Finally, they suggest a specialization of the left hemisphere in the attentional selection of fine-grained acoustic information.
引用
收藏
页码:9252 / 9261
页数:10
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