VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells

被引：27

作者：

Bai, Xiaowen ^{[1
]}

Sadat, Sanga ^{[1
]}

Gehmert, Sebastian ^{[1
]}

Alt, Eckhard ^{[1
]}

Song, Yao-Hua ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77054 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 24期

关键词：

stem cell; c-kit; infarction;

D O I：

10.1016/j.febslet.2007.08.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is known that c-kit(+) cells are increased in heart after infarction. The exact origins of the cardiac c-kit+ cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit+ cells. Our data show that the number of c-kit(+) cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4681 / 4684

页数：4

共 17 条

[1] Adult cardiac stem cells are multipotent and support myocardial regeneration [J].

Beltrami, AP ;

Barlucchi, L ;

Torella, D ;

Baker, M ;

Limana, F ;

Chimenti, S ;

Kasahara, H ;

Rota, M ;

Musso, E ;

Urbanek, K ;

Leri, A ;

Kajstura, J ;

Nadal-Ginard, B ;

Anversa, P .

CELL, 2003, 114 (06) :763-776

[2] Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells [J].

Crossno, Joseph T., Jr. ;

Majka, Susan M. ;

Grazia, Todd ;

Gill, Ronald G. ;

Klemm, Dwight J. .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (12) :3220-3228

[3] Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines [J].

Fazel, Shafie ;

Cimini, Massimo ;

Chen, Liwen ;

Li, Shuhong ;

Angoulvant, Denis ;

Fedak, Paul ;

Verma, Subodh ;

Weisel, Richard D. ;

Keating, Armand ;

Li, Ren-Ke .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1865-1877

[4] Adipose-derived adult stem cells: isolation, characterization, and differentiation potential [J].

Gimble, JM ;

Guilak, F .

CYTOTHERAPY, 2003, 5 (05) :362-369

[5] Improvement of postnatal neovascularization by human adipose tissue-derived stem cells [J].

Miranville, A ;

Heeschen, C ;

Sengenès, C ;

Curat, CA ;

Busse, R ;

Bouloumié, A .

CIRCULATION, 2004, 110 (03) :349-355

[6] Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction [J].

Miyahara, Y ;

Nagaya, N ;

Kataoka, M ;

Yanagawa, B ;

Tanaka, K ;

Hao, H ;

Ishino, K ;

Ishida, H ;

Shimizu, T ;

Kangawa, K ;

Sano, S ;

Okano, T ;

Kitamura, S ;

Mori, H .

NATURE MEDICINE, 2006, 12 (04) :459-465

[7] Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells [J].

Nakagami, H ;

Maeda, K ;

Morishita, R ;

Iguchi, S ;

Nishikawa, T ;

Takami, Y ;

Kikuchi, Y ;

Saito, Y ;

Tamai, K ;

Ogihara, T ;

Kaneda, Y .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (12) :2542-2547

[8] Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure [J].

Oedayrajsingh-Varma, MJ ;

van Ham, SM ;

Knippenberg, M ;

Helder, MN ;

Klein-Nulend, J ;

Schouten, TE ;

Ritt, MJPF ;

van Milligen, FJ .

CYTOTHERAPY, 2006, 8 (02) :166-177

[9] Multilineage potential of adult human mesenchymal stem cells [J].

Pittenger, MF ;

Mackay, AM ;

Beck, SC ;

Jaiswal, RK ;

Douglas, R ;

Mosca, JD ;

Moorman, MA ;

Simonetti, DW ;

Craig, S ;

Marshak, DR .

SCIENCE, 1999, 284 (5411) :143-147

[10] Plasticity of human adipose lineage cells toward endothelial cells -: Physiological and therapeutic perspectives [J].

Planat-Benard, V ;

Silvestre, JS ;

Cousin, B ;

André, M ;

Nibbelink, M ;

Tamarat, R ;

Clergue, M ;

Manneville, C ;

Saillan-Barreau, C ;

Duriez, M ;

Tedgui, A ;

Levy, B ;

Pènicaud, L ;

Casteilla, L .

CIRCULATION, 2004, 109 (05) :656-663

← 1 2 →