Characterisation of the transition states for protein folding: towards a new level of mechanistic detail in protein engineering analysis

被引：92

作者：

Oliveberg, M ^{[1
]}

机构：

[1] Umea Univ, S-90187 Umea, Sweden

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(00)00171-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of protein folding now offers considerable excitement. Comparative studies of the transition-state structures for a series of protein families with analogous structures have helped to uncover the overall rules for protein folding. In addition, new protein engineering experiments that continuously follow the growth of the folding nucleus have started to fill in the missing details.

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页码：94 / 100

页数：7

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[1] Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures [J].

Alm, E ;

Baker, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11305-11310

[2] Matching theory and experiment in protein folding [J].

Alm, E ;

Baker, D .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (02) :189-196

[3] A surprising simplicity to protein folding [J].

Baker, D .

NATURE, 2000, 405 (6782) :39-42

[4] Protein folding dynamics: Quantitative comparison between theory and experiment [J].

Burton, RE ;

Myers, JK ;

Oas, TG .

BIOCHEMISTRY, 1998, 37 (16) :5337-5343

[5]

Chiti F, 1999, NAT STRUCT BIOL, V6, P1005

[6] Two proteins with the same structure respond very differently to mutation: The role of plasticity in protein stability [J].

Cota, E ;

Hamill, SJ ;

Fowler, SB ;

Clarke, J .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 302 (03) :713-725

[7] β-sheet proteins with nearly identical structures have different folding intermediates [J].

Dalessio, PM ;

Ropson, IJ .

BIOCHEMISTRY, 2000, 39 (05) :860-871

[8] Identifying the protein folding nucleus using molecular dynamics [J].

Dokholyan, NV ;

Buldyrev, SV ;

Stanley, HE ;

Shakhnovich, EI .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 296 (05) :1183-1188

[9] Protein folding intermediates and pathways studied by hydrogen exchange [J].

Englander, SW .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2000, 29 :213-238

[10] Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9 [J].

Ferguson, N ;

Capaldi, AP ;

James, R ;

Kleanthous, C ;

Radford, SE .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 286 (05) :1597-1608

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