Fully intermolecular nickel-catalyzed three-component couplings via internal redox

被引：65

作者：

Herath, Ananda ^{[1
]}

Li, Wei ^{[1
]}

Montgomery, John ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 02期

关键词：

D O I：

10.1021/ja0781846

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two distinct nickel-catalyzed fully intermolecular three-component couplings are described. The catalytic addition of enals, alkynes, and alcohols provided gamma,delta-unsaturated esters, whereas the catalytic addition of enones, alkynes, and aldehydes provides stereodefined, unsymmetrical 2-allyl-1,3-diketones. An internal redox process allows the reactions to proceed in the absence of reducing agents. On the basis of deuterium-labeling studies, a likely mechanistic pathway is proposed.

引用

页码：469 / +

页数：4

共 52 条

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