Molecular genetic investigations of autism

被引：19

作者：

Maestrini, E ^{[1
]}

Marlow, AJ ^{[1
]}

Weeks, DE ^{[1
]}

Monaco, AP ^{[1
]}

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford, England

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 1998年 / 28卷 / 05期

基金：

英国惠康基金;

关键词：

genetics; autism; genotyping;

D O I：

10.1023/A:1026056522602

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Genetic factors are likely to play a major role in the etiology of autism. The genetics of the disorder is however complex, probably involving the action of several genes. In an attempt to identify autism susceptibility loci we are currently undertaking a systematic screening of the whole human genome using multiplex families. We describe the resources and the methods needed to achieve such a task, including extensive collection of family data, semiautomated genotyping technology, and specialized statistical approaches for linkage analysis of complex traits.

引用

页码：427 / 437

页数：11

共 67 条

[1] ELEVATED BLOOD SEROTONIN IN AUTISTIC PROBANDS AND THEIR 1ST-DEGREE RELATIVES [J].

ABRAMSON, RK ;

WRIGHT, HH ;

CARPENTER, R ;

BRENNAN, W ;

LUMPUY, O ;

COLE, E ;

YOUNG, SR .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1989, 19 (03) :397-407

[2]

ADAMSON D, 1995, AM J HUM GENET, V57, P619

[3] WHOLE-BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS [J].

ANDERSON, GM ;

FREEDMAN, DX ;

COHEN, DJ ;

VOLKMAR, FR ;

HODER, EL ;

MCPHEDRAN, P ;

MINDERAA, RB ;

HANSEN, CR ;

YOUNG, JG .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, 1987, 28 (06) :885-900

[4] AUTISM AS A STRONGLY GENETIC DISORDER - EVIDENCE FROM A BRITISH TWIN STUDY [J].

BAILEY, A ;

LECOUTEUR, A ;

GOTTESMAN, I ;

BOLTON, P ;

SIMONOFF, E ;

YUZDA, E ;

RUTTER, M .

PSYCHOLOGICAL MEDICINE, 1995, 25 (01) :63-77

[5] DUPLICATION OF CHROMOSOME 15Q11-13 IN 2 INDIVIDUALS WITH AUTISTIC DISORDER [J].

BAKER, P ;

PIVEN, J ;

SCHWARTZ, S ;

PATIL, S .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1994, 24 (04) :529-535

[6] SUSCEPTIBILITY TO HUMAN TYPE-1 DIABETES AT IDDM2 IS DETERMINED BY TANDEM REPEAT VARIATION AT THE INSULIN GENE MINISATELLITE LOCUS [J].

BENNETT, ST ;

LUCASSEN, AM ;

GOUGH, SCL ;

POWELL, EE ;

UNDLIEN, DE ;

PRITCHARD, LE ;

MERRIMAN, ME ;

KAWAGUCHI, Y ;

DRONSFIELD, MJ ;

POCIOT, F ;

NERUP, J ;

BOUZEKRI, N ;

CAMBONTHOMSEN, A ;

RONNINGEN, KS ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (03) :284-292

[7] A locus for bipolar affective disorder on chromosome 4p [J].

Blackwood, DHR ;

He, L ;

Morris, SW ;

McLean, A ;

Whitton, C ;

Thomson, M ;

Walker, MT ;

Woodburn, K ;

Sharp, CM ;

Wright, AF ;

Shibasaki, Y ;

StClair, DM ;

Porteous, DJ ;

Muir, WJ .

NATURE GENETICS, 1996, 12 (04) :427-430

[8] A CASE - CONTROL FAMILY HISTORY STUDY OF AUTISM [J].

BOLTON, P ;

MACDONALD, H ;

PICKLES, A ;

RIOS, P ;

GOODE, S ;

CROWSON, M ;

BAILEY, A ;

RUTTER, M .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, 1994, 35 (05) :877-900

[9]

BROWN DL, 1994, AM J HUM GENET, V54, P544

[10]

BUNDEY S, 1994, DEV MED CHILD NEUROL, V36, P736

← 1 2 3 4 5 6 7 →