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Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene

被引：168
作者：
Berthet, FX
Lagranderie, M
Gounon, P
Laurent-Winter, C
Ensergueix, D
Chavarot, P
Thouron, F
Maranghi, E
Pelicic, V
Portnoï, D
Marchal, G
Gicquel, B
机构：
[1] Inst Pasteur, Unite Genet Mycobacterienne, F-75724 Paris 15, France
[2] Inst Pasteur, Lab BCG, F-75724 Paris, France
[3] Inst Pasteur, Stn Cent Microscopie Elect, F-75724 Paris 15, France
[4] Inst Pasteur, Lab Electrophorese Bidimens, F-75724 Paris 15, France
[5] Inst Pasteur, Unite Physiopathol Infect, F-75724 Paris 15, France
来源：
SCIENCE | 1998年 / 282卷 / 5389期
关键词：
D O I：
10.1126/science.282.5389.759
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis and M, bovis Bacille Calmette-Guerin in cultured macrophages and mice. Reintroduction of erp into the mutants restored their ability to multiply. These results indicate that erp contributes to the virulence of M. tuberculosis.
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页码：759 / 762
页数：4
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