5-Hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart

被引：20

作者：

Sakamoto, K ^{[1
]}

Yamazaki, J ^{[1
]}

Nagao, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Pharmacol & Toxicol, Bunkyo Ku, Tokyo 113, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 348卷 / 01期

关键词：

ischemia; myocardial; K(+); extracellular; 5-hydroxydecanoate; ouabain;

D O I：

10.1016/S0014-2999(98)00238-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to determine the effect of 5-hydroxydecanoate (5-HD) on extracellular K(+) levels during global ischemia for 30 min employing K(+)-sensitive electrodes in isolated guinea-pig hearts. 5-HD (100 mu M) reduced the K(+) accumulation during the early period of ischemia, but did not inhibit the elevation of extracellular K(+) in the latter half of the ischemic period which was selectively enhanced by ouabain (3 mu M) Thus, 5-HD appears to exert a similar mode of action as glibenclamide on extracellular K(+) accumulation in the ischemic guinea-pig hearts. The present study also strengthens the previous conclusion that an ATP-sensitive K(+) channel contributes only to the initial increasing phase of extracellular K(+) accumulation during ischemia in guinea-pig hearts. (C) 1998 Elsevier Science B.V.

引用

页码：31 / 35

页数：5

共 24 条

[1] BLOCKADE OF ISCHEMIC PRECONDITIONING IN DOGS BY THE NOVEL ATP DEPENDENT POTASSIUM CHANNEL ANTAGONIST SODIUM 5-HYDROXYDECANOATE [J].