Severe falciparum malaria in children: Current understanding of pathophysiology and supportive treatment

被引:246
作者
Newton, CRJC
Krishna, S
机构
[1] Wolfson Ctr Magnet Technol, Inst Child Hlth, Neurosci Unit, London WC1N 2AP, England
[2] St George Hosp, Sch Med, Dept Cell & Mol Sci, Div Infect Dis, London SW17 0RE, England
基金
英国惠康基金;
关键词
falciparum malaria; pathophysiology; children; adjunct therapy;
D O I
10.1016/S0163-7258(98)00008-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Severe falciparum malaria is one of the most lethal parasitic infections in the world and is responsible for more than one million deaths in African children per year. Changes to management over the last 40 years have not improved survival. A reduction in the mortality and morbidity may only come about by a better understanding of the pathophysiological processes that are responsible for severe disease and that determine the outcome before antimalarials have had time to work. This review discusses potential adjunctive therapies for severe malaria that are under development following such derailed clinical and pathophysiological studies. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:1 / 53
页数:53
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