Regulation of lymphoid development, differentiation, and function by the notch pathway

被引：350

作者：

Maillard, I ^{[1
]}

Fang, T

Pear, WS

机构：

[1] Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2005年 / 23卷

关键词：

Notch; T lymphocytes; B lymphocytes; thymus; hematopoietic stem cells;

D O I：

10.1146/annurev.immunol.23.021704.115747

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Notch pathway is gaining increasing recognition as a key regulator of developmental choices, differentiation, and function throughout the hematolymphoid system. Notch controls the generation of hematopoietic stem cells during embryonic development and may affect their subsequent homeostasis. Commitment to the T cell lineage and subsequent stages of early thymopoiesis is critically regulated by Notch. Recent data indicate that Notch can also direct the differentiation and activity of peripheral T and B cells. Thus, the full spectrum of Notch effects is just beginning to be understood. In this review, we discuss this explosion of knowledge as well as current controversies and challenges in the field.

引用

页码：945 / 974

页数：30

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