Synthetic dihydropacidamycin antibiotics: A modified spectrum of activity for the pacidamycin class

被引：27

作者：

Boojamra, CG ^{[1
]}

Lemoine, RC ^{[1
]}

Blais, J ^{[1
]}

Vernier, NG ^{[1
]}

Stein, KA ^{[1
]}

Magon, A ^{[1
]}

Chamberland, S ^{[1
]}

Hecker, SJ ^{[1
]}

Lee, VJ ^{[1
]}

机构：

[1] Essential Therapeut Inc, Mountain View, CA 94043 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00682-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dihydropacidamycins having an antibacterial spectrum modified from that of the natural product pacidamycins and mureidomycins have been synthesized. Synthetic dihydropacidamycins with noteworthy antibacterial activity against wild-type and resistant Escherichia coli have been identified (MIC = 4-8 mug/mL). Some dihydropacidamycins are shown to have activity against multi-resistant clinical strains of Mycobacterium tuberculosis. Compounds of this class are inhibitors of the cell wall biosynthetic enzyme, MraY. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3305 / 3309

页数：5

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