Recognition and management of the gastrointestinal and hepatic immune-related adverse events

被引：12

作者：

Tan, Bei ^{[1
]}

Li, Yue ^{[1
]}

Xu, Yan ^{[2
]}

Chen, Minjiang ^{[2
]}

Wang, Mengzhao ^{[2
]}

Qian, Jiaming ^{[1
]}

机构：

[1] Peking Union Med Coll & Chinese Acad Med Sci, Dept Gastroenterol, Peking Union Med Coll Hosp, 1 Shuaifuyuan, Beijing 100730, Peoples R China

[2] Peking Union Med Coll & Chinese Acad Med Sci, Dept Resp & Crit Care Med, Peking Union Med Coll Hosp, 1 Shuaifuyuan, Beijing 100730, Peoples R China

来源：

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY | 2020年 / 16卷 / 03期

关键词：

gastrointestinal; hepatic; immune checkpoint inhibitor; immune-related adverse event; immunotherapy; CHECKPOINT-BLOCKADE; ADVANCED MELANOMA; IPILIMUMAB; IMMUNOTHERAPY; CANCER; MICROBIOME; NIVOLUMAB; SURVIVAL; THERAPY;

D O I：

10.1111/ajco.13317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Immunotherapy is revolutionizing the treatment paradigm for a broad spectrum of malignancies. However, the immune checkpoint inhibitors also cause a unique set of toxicities. In the digestive system, this has consisted for the most part as colitis and hepatotoxicity, but also include less-common manifestations. Baseline screening, early identification, timely diagnosis, rapid and adequate treatment can significantly minimize the toxicity of immunotherapy and improve prognosis. This article provides a comprehensive review of gastrointestinal and hepatic immune-related toxicities, including incidence, mechanism, clinical manifestation, diagnosis, treatment, and guidelines for resumption of immune checkpoint inhibitor therapy.

引用

收藏

页码：95 / 102

页数：8

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