Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model

被引：49

作者：

Dierssen, M ^{[1
]}

Vallina, IF ^{[1
]}

Baamonde, C ^{[1
]}

Lumbreras, MA ^{[1
]}

MartinezCue, C ^{[1
]}

Calatayud, SG ^{[1
]}

Florez, J ^{[1
]}

机构：

[1] UNIV CANTABRIA,SCH MED,DEPT PHYSIOL & PHARMACOL,SANTANDER 39011,SPAIN

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1996年 / 95卷 / 01期

关键词：

Down syndrome; partial trisomy 16; hippocampus; cyclic AMP;

D O I：

10.1016/0165-3806(96)00071-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Behavioral and learning disturbances have been found in mice with partial trisomy 16, a new model for Down syndrome. Basal production of cyclic AMP in the hippocampus of trisomic mice was shown to be impaired. In addition, the responses of adenylyl cyclase to the stimulation of beta-adrenoceptors with isoprenaline and of the catalytic subunit with forskolin were both severely depressed.

引用

页码：122 / 124

页数：3

共 13 条

[1] SIMPLE AND SENSITIVE SATURATION ASSAY METHOD FOR MEASUREMENT OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE
BROWN, BL
ALBANO, JDM
EKINS, RP
SGHERZI, AM
TAMPION, W
[J]. BIOCHEMICAL JOURNAL, 1971, 121 (03) : 561 - +
[2] BYRNE JH, 1993, ADV SEC MESS PHOSPH, V27, P47
[3] Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: Altered behavior in the elevated plus maze and open field
CoussonsRead, ME
Crnic, LS
[J]. BEHAVIOR GENETICS, 1996, 26 (01) : 7 - 13
[4] Davisson Muriel T., 1993, V384, P117
[5] 2 FUNCTIONAL COMPONENTS OF THE HIPPOCAMPAL MEMORY SYSTEM
EICHENBAUM, H
OTTO, T
COHEN, NJ
[J]. BEHAVIORAL AND BRAIN SCIENCES, 1994, 17 (03) : 449 - 472
[6] MOUSE TRISOMY-16 - AN ANIMAL-MODEL OF HUMAN TRISOMY-21 (DOWN SYNDROME)
EPSTEIN, CJ
COX, DR
EPSTEIN, LB
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 450 (JUN) : 157 - 168
[7] A BEHAVIORAL-ASSESSMENT OF TS65DN MICE - A PUTATIVE DOWN-SYNDROME MODEL
ESCORIHUELA, RM
FERNANDEZTERUEL, A
VALLINA, IF
BAAMONDE, C
LUMBRERAS, MA
DIERSSEN, M
TOBENA, A
FLOREZ, J
[J]. NEUROSCIENCE LETTERS, 1995, 199 (02) : 143 - 146
[8] LONG-TERM INCREASES IN THE NUMERICAL DENSITY OF SYNAPSES IN THE CHICK LOBUS-PAROLFACTORIUS AFTER PASSIVE-AVOIDANCE TRAINING
HUNTER, A
STEWART, MG
[J]. BRAIN RESEARCH, 1993, 605 (02) : 251 - 255
[9] DOWN SYNDROME FIBROBLASTS ARE HYPERRESPONSIVE TO BETA-ADRENERGIC STIMULATION
MCSWIGAN, JD
HANSON, DR
LUBINIECKI, A
HESTON, LL
SHEPPARD, JR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12): : 7670 - 7673
[10] A MOUSE MODEL FOR DOWN-SYNDROME EXHIBITS LEARNING AND BEHAVIOR DEFICITS
REEVES, RH
IRVING, NG
MORAN, TH
WOHN, A
KITT, C
SISODIA, SS
SCHMIDT, C
BRONSON, RT
DAVISSON, MT
[J]. NATURE GENETICS, 1995, 11 (02) : 177 - 184

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