Genomic mapping of resistance to Marek's disease

被引:46
作者
Bumstead, N [1 ]
机构
[1] AFRC, Inst Anim Hlth, Compton Lab, Newbury RG20 7NN, Berks, England
关键词
D O I
10.1080/03079459808419296
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
It seems likely that genomic mapping will be able to identify the genes responsible for genetic resistance to Marek's disease, shedding light on the processes of pathogenesis and the immune response at the same time. Already the indication that the NK region is implicated in genetic resistance suggests many avenues of investigation. The growing evidence that quite large regions of the chicken genome have a common gene order with that of humans or mice suggests exciting possibilities for using information from these well-mapped species. It remains to be seen whether it will be possible to utilize linked markers to select for the resistance genes or whether efficient selection will require isolation of the mapped genes.
引用
收藏
页码:S78 / S81
页数:4
相关论文
共 19 条
  • [1] MAREKS-DISEASE - EFFECTS OF B-HISTOCOMPATIBILITY ALLOALLELES IN RESISTANT AND SUSCEPTIBLE CHICKEN LINES
    BRILES, WE
    STONE, HA
    COLE, RK
    [J]. SCIENCE, 1977, 195 (4274) : 193 - 195
  • [2] A PRELIMINARY LINKAGE MAP OF THE CHICKEN GENOME
    BUMSTEAD, N
    PALYGA, J
    [J]. GENOMICS, 1992, 13 (03) : 690 - 697
  • [3] Quantification of Marek's disease virus in chicken lymphocytes using the polymerase chain reaction with fluorescence detection
    Bumstead, N
    Sillibourne, J
    Rennie, M
    Ross, N
    Davison, F
    [J]. JOURNAL OF VIROLOGICAL METHODS, 1997, 65 (01) : 75 - 81
  • [4] Calnek B. W., 1985, Marek's disease: scientific basis and methods of control, P293
  • [5] STUDIES ON GENETIC RESISTANCE TO MAREKS DISEASE
    COLE, RK
    [J]. AVIAN DISEASES, 1968, 12 (01) : 9 - &
  • [6] T-CELL ANTIGEN SYSTEM OF CHICKENS - LY4 AND MAREKS-DISEASE
    FREDERICKSEN, TL
    LONGENECKER, BM
    PAZDERKA, F
    GILMOUR, DG
    RUTH, RF
    [J]. IMMUNOGENETICS, 1977, 5 (06) : 535 - 552
  • [7] BU-1 AND TH-1, 2 LOCI DETERMINING SURFACE-ANTIGENS OF B OR T LYMPHOCYTES IN CHICKEN
    GILMOUR, DG
    BRAND, A
    DONNELLY, N
    STONE, HA
    [J]. IMMUNOGENETICS, 1976, 3 (06) : 549 - 563
  • [8] Partial conservation of the mammalian NRAMP1 syntenic group on chicken Chromosome 7
    GirardSantosuosso, O
    Bumstead, N
    Lantier, I
    Protais, J
    Colin, P
    Guillot, JF
    Beaumont, C
    Malo, D
    Lantier, F
    [J]. MAMMALIAN GENOME, 1997, 8 (08) : 614 - 616
  • [9] HANSEN MP, 1967, POULTRY SCI, V46, P1268
  • [10] GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS
    LANDER, E
    KRUGLYAK, L
    [J]. NATURE GENETICS, 1995, 11 (03) : 241 - 247