Steroidal glycosides from Hoodia gordonii

被引：31

作者：

Dall'Acqua, Stefano ^{[1
]}

Innocenti, Gabbriella ^{[1
]}

机构：

[1] Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

来源：

STEROIDS | 2007年 / 72卷 / 6-7期

关键词：

Hoodia gordonii; Asclepiadaceae; steroidal glycosides;

D O I：

10.1016/j.steroids.2007.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten new C-21-steroidal derivatives, namely gordonosides A-L (1-10) were isolated from a chloroform extract of the aerial parts of Hoodia gordonii, a plant widely used in the nutraceutical market as an ingredient of weight loss supplements. Compounds (2-10) are based on 3 beta,14 beta-dihydroxy-pregn-5-en-17-beta one aglycone (1). Their structures were characterized on the basis of HR-MS spectrometry and both 1D and 2D NMR techniques. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：559 / 568

页数：10

共 7 条

[1] A succulent cure to end obesity [J].

Habeck, M .

DRUG DISCOVERY TODAY, 2002, 7 (05) :280-281

[2] STUDIES ON THE CONSTITUENTS OF ASCLEPIADACEAE PLANTS .68. 4 PREGNANE GLYCOSIDES, BOUCEROSIDE-AI, BOUCEROSIDE-AII, BOUCEROSIDE-BI AND BOUCEROSIDE-BII, FROM BOUCEROSIA-AUCHERIANA [J].

HAYASHI, K ;

IIDA, I ;

NAKAO, Y ;

KANEKO, K .

PHYTOCHEMISTRY, 1988, 27 (12) :3919-3924

[3] Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside [J].

MacLean, DB ;

Luo, LG .

BRAIN RESEARCH, 2004, 1020 (1-2) :1-11

[4] STUDIES ON THE CONSTITUENTS OF ASCLEPIADACEAE PLANT .57. THE STRUCTURES OF 6 GLYCOSIDES, WILFOSIDE-C1N, WILFOSIDE-C2N, WILFOSIDE-C3N, WILFOSIDE-C1G, WILFOSIDE-C2G AND WILFOSIDE-C3G, WITH NOVEL SUGAR CHAIN CONTAINING A PAIR OF OPTICALLY ISOMERIC SUGARS [J].

TSUKAMOTO, S ;

HAYASHI, K ;

MITSUHASHI, H .

TETRAHEDRON, 1985, 41 (05) :927-934

[5]

van Heerden F.R., 2002, US Patent, Patent No. [6376675B1, 6376675]

[6] Five new C21 steroidal glycosides from Cynanchum komarovii Al.!Iljinski [J].

Wang, LQ ;

Shen, YM ;

Xu, X ;

Wei, YQ ;

Zhou, J .

STEROIDS, 2004, 69 (05) :319-324

[7]

Warashina T, 2000, CHEM PHARM BULL, V48, P516

← 1 →