Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

被引:1278
作者
Yamamoto, Y [1 ]
Gaynor, RB [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Med, Div Hematol Oncol,Harold Simmons Canc Ctr, Dallas, TX 75390 USA
关键词
D O I
10.1172/JCI11914
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:135 / 142
页数:8
相关论文
共 47 条
[1]  
Adams J, 1999, CANCER RES, V59, P2615
[2]   IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].
AUPHAN, N ;
DIDONATO, JA ;
ROSETTE, C ;
HELMBERG, A ;
KARIN, M .
SCIENCE, 1995, 270 (5234) :286-290
[3]   The NF-kappa B and I kappa B proteins: New discoveries and insights [J].
Baldwin, AS .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683
[4]  
BALDWIN AS, 2001, IN PRESS J CLIN INVE
[5]   Control of apoptosis by Rel/NF-κB transcription factors [J].
Barkett, M ;
Gilmore, TD .
ONCOGENE, 1999, 18 (49) :6910-6924
[6]  
BOCHNER BS, 1994, ANNU REV IMMUNOL, V12, P295
[7]  
COLLINS T, 2001, IN PRESS J CLIN INVE
[8]   Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell [J].
De Bosscher, K ;
Vanden Berghe, W ;
Vermeulen, L ;
Plaisance, S ;
Boone, E ;
Haegeman, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :3919-3924
[9]   Glucocorticoid-mediated repression of nuclear factor-kappa B-dependent transcription involves direct interference with transactivation [J].
DeBosscher, K ;
Schmitz, ML ;
Vanden Berghe, W ;
Plaisance, S ;
Fiers, W ;
Haegeman, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13504-13509
[10]   Inhibition of interleukin-1-stimulated NF-kappa B RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity [J].
Egan, LJ ;
Mays, DC ;
Huntoon, CJ ;
Bell, MP ;
Pike, MG ;
Sandborn, WJ ;
Lipsky, JJ ;
McKean, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26448-26453