Hair follicle stem cells

被引:109
作者
Lavker, RM [1 ]
Sun, TT
Oshima, H
Barrandon, Y
Akiyama, M
Ferraris, C
Chevalier, G
Favier, B
Jahoda, CAB
Dhouailly, D
Panteleyev, AA
Christiano, AM
机构
[1] Northwestern Univ, Feinburg Sch Med, Dept Dermatol, Chicago, IL 60611 USA
[2] NYU, Sch Med, Dept Dermatol, New York, NY USA
[3] St Marianna Univ, Sch Med, Dept Plast & Reconstruct Surg, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan
[4] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan
[5] Ecole Normale Super, Dept Biol, F-75231 Paris, France
[6] Univ Grenoble 1, CNRS, UMR 5538, Equipe Biol Differenciat Epitheliale, Grenoble, France
[7] Columbia Univ, Dept Dermatol, New York, NY USA
[8] Columbia Univ, Dept Genet & Dev, New York, NY USA
关键词
bulge; cell plasticity; epithelial stem cells; multipotent;
D O I
10.1046/j.1523-1747.2003.12169.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle. One of the main concepts to emerge from this workshop is that follicular epithelial stem cells are multipotent, capable of giving rise not only to all the cell types of the hair, but also to the epidermis and the sebaceous gland. Furthermore, such multipotent stem cells may represent the ultimate epidermal stem cell. Another example of epithelial stem cell and transit amplifying cell plasticity, was the demonstration that adult corneal epithelium, under the influence of embryonic skin dermis could form an epidermis as well as hair follicles. With regards to the location of follicular epithelial stem cells, immunohistochemical and ultrastructural data was presented, indicating that cells with stem cell attributes were localized to the prominent bulge region of developing human fetal hair follicles. Finally, a new notion was put forth concerning the roles that the bulge-located stem cells and the hair germ cells played with respect to the hair cycle.
引用
收藏
页码:28 / 38
页数:11
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