Susceptibility of Yersinia pestis to novel and conventional antimicrobial agents

被引：23

作者：

Frean, J

Klugman, KP ^{[1
]}

Arntzen, L

Bukofzer, S

机构：

[1] Univ Witwatersrand, MRC, NHLS Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa

[2] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Johannesburg, South Africa

[3] Emory Univ, Dept Int Hlth, Atlanta, GA 30322 USA

[4] Abbott Labs, Chicago, IL USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 52卷 / 02期

关键词：

plague; antibiotics; fluoroquinolones; macrolides; ketolides;

D O I：

10.1093/jac/dkg363

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: To determine the susceptibility of southern African strains of Yersinia pestis to novel as well as conventional antimicrobial agents. Materials and methods: The MICs of 28 strains of Yersinia pestis from a southern African plague focus were determined by agar dilution. Results: The most active agents were cefditoren and the fluoroquinolones, both conventional and novel. The in vitro activity of macrolides was poor against this member of the Enterobacteriaceae. Conclusion: Further investigation of the novel quinolones olamufloxacin (HSR 903) and ABT 492 in animal models of plague would seem to be justified.

引用

页码：294 / 296

页数：3

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