Sonogashira coupling using bulky palladium-phenanthryl imidazolium carbene catalysis

被引：108

作者：

Ma, YD

Song, C

Jiang, W

Wu, QS

Wang, Y

Liu, XY

Andrus, MB

机构：

[1] Shandong Univ, Chem Coll, Jinan 250100, Peoples R China

[2] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 18期

关键词：

D O I：

10.1021/ol035147k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Bulky phenanthracenyl imidazolium-derived carbene ligands were investigated for copper-free Sonogashira coupling with terminal acetylenes. Aryl bromides and iodides gave coupled products in excellent yields from the Pd(PPh3)(2)Cl-2 complex with potassium t-butoxide and 18-crown-6 in THF. A remarkable dependence on the size of the ligand was found. The highest yields were obtained with the bulky 2,9-dicyclohexyl-10-phenanthryl ligand 5.

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页码：3317 / 3319

页数：3

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