Polymorphism of TAPASIN and its linkage disequilibria with HLA class II genes in the Japanese population

被引：9

作者：

Furukawa, H

Kashiwase, K

Yabe, T

Ishikawa, Y

Akaza, T

Tadokoro, K

Tohma, S

Inoue, T

Tokunaga, K

Yamamoto, K

Juji, T

机构：

[1] Japanese Res Cross, Cent Blood Ctr, Dept Res, Shibuya Ku, Tokyo 150, Japan

[2] Univ Tokyo, Fac Med, Dept Med & Phys Therapy, Bunkyo Ku, Tokyo 113, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Human Genet, Bunkyo Ku, Tokyo 113, Japan

来源：

TISSUE ANTIGENS | 1998年 / 52卷 / 03期

关键词：

HLA class I assembly; polymorphism; RFLP; tapasin;

D O I：

10.1111/j.1399-0039.1998.tb03044.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tapasin plays an important role in HLA class I assembly. The gene has been mapped on the human MHC region. We identified two alleles of TAPASIN in the Japanese population and analyzed the association of the alleles with HLA-DPB1, -DQB1 and -DRB1 alleles. The allele frequencies of TAPASIN*01 and *02 were estimated to be 0.37 and 0.63, respectively in the Japanese population. TAPASIN showed strong linkage disequilibrium with the HLA-DPB1 locus. Several frequent four-locus haplotypes were identified, including DRB1*0901-DQB1*0303-DPB1*0501-TAPASIN*02 DRB1*0901-DQB1*0303-DPB1*0201-TAPASIN*02 and DRB1*1302-DQB1*0604-DPB1*0401-TAPASIN*02.

引用

页码：279 / 281

页数：3

共 9 条

[1] TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC [J].