Metabolic surgery for type 2 diabetes

被引：17

作者：

Ahn, Soo Min ^{[1
]}

Rubino, Francesco ^{[1
]}

机构：

[1] New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Surg, New York, NY USA

来源：

YEAR IN DIABETES AND OBESITY | 2010年 / 1212卷

关键词：

bariatric surgery; metabolic surgery; type; 2; diabetes; gastric bypass; duodenal-jejunal bypass; glucose hemostasis; ROUX-EN-Y; GASTRIC BYPASS-SURGERY; DUODENAL-JEJUNAL BYPASS; INTENTIONAL WEIGHT-LOSS; LONG-TERM MORTALITY; BETA-CELL FUNCTION; BODY-MASS INDEX; BARIATRIC SURGERY; BILIOPANCREATIC DIVERSION; MORBIDLY OBESE;

D O I：

10.1111/j.1749-6632.2011.05984.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Conventional bariatric operations, including Roux-en-Y gastric bypass (RYGB), laparoscopic adjustable gastric banding, and biliopancreatic diversion (BPD) appear to be a safe and effective treatment for many severely obese patients with type 2 diabetes mellitus (T2DM). These operations improve glucose homeostasis through a variety of mechanisms, however, not only due to reduced food intake and body weight. Research to elucidate the weight-independent antidiabetic mechanisms of gastrointestinal (GI) surgery and to clarify the molecular mechanisms responsible for the benefits of GI surgery on glucose homeostasis is a compelling research objective. We review the existing knowledge regarding the clinical outcomes and of the mechanisms of GI surgery to treat T2DM.

引用

页码：E37 / E45

页数：9

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