The Rad51 and Dmc1 recombinases: a non-identical twin relationship

被引：138

作者：

Masson, JY ^{[1
]}

West, SC ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(00)01742-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A double-strand break in genomic DNA that remains unrepaired can be lethal for a cell, indeed, the integrity of the genome is paramount for survival. It is therefore surprising that some cells deliberately introduce double-strand breaks at certain times during their life cycle. Why might they do this? What are the benefits? How are these breaks repaired? The answers to these questions lie in understanding the basis of meiotic recombination, the process that leads to genetic variation. This review summarizes the key roles played by the two recombinases, Dmc1 and Rad51, in the faithful repair of DNA breaks.

引用

页码：131 / 136

页数：6

共 49 条

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