Identification and characterization of mouse SSX genes:: a multigene family on the X chromosome with restricted cancer/testis expression

被引：20

作者：

Chen, YT ^{[1
]}

Alpen, B

Ono, T

Gure, AO

Scanlan, MA

Biggs, WH

Arden, K

Nakayama, E

Old, LJ

机构：

[1] Cornell Univ, Weill Med Coll, New York, NY 10021 USA

[2] Okayama Univ, Sch Med, Okayama 7008558, Japan

[3] Mem Sloan Kettering Canc Ctr, New York Branch, Ludwig Inst Canc Res, New York, NY 10021 USA

[4] Ambit Biosci, San Diego, CA 92121 USA

[5] Ludwig Inst Canc Res, San Diego Branch, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

来源：

GENOMICS | 2003年 / 82卷 / 06期

关键词：

cancer/testis antigens; tumor immunology; cancer vaccine;

D O I：

10.1016/S0888-7543(03)00183-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Human SSX was first identified as the gene involved in the t(X;18) translocation in synovial sarcoma. SSX is a multigene family, with 9 complete genes on chromosome Xp11. Normally expressed almost exclusively in testis, SSX mRNA is expressed in various human tumors, defining SSX as a cancer/testis antigen. We have now cloned the mouse ortholog of SSX. Mouse SSX genes can be divided into Ssxa and Ssxb subfamilies based on sequence homology. Ssxa has only one member, whereas 12 Ssxb genes, Ssxb1 to Ssxb12, were identified by cDNA cloning from mouse testis and mouse tumors. Both Ssxa and Ssxb are located on chromosome X and show tissue-restricted mRNA expression to testis among normal tissues. All putative human and mouse SSX proteins share conserved KRAB and SSX-RD domains. Mouse tumors were found to express some, but not all, Ssxb genes, similar to the SSX activation in human tumors. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：628 / 636

页数：9

共 18 条

[1] Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes [J].