Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study

被引：54

作者：

Vatassery, GT ^{[1
]}

Fahn, S

Kuskowski, MA

机构：

[1] Univ Minnesota, VA Med Ctr, Res Serv 151, Minneapolis, MN 55417 USA

[2] Univ Minnesota, VA Med Ctr, GRECC, Minneapolis, MN 55417 USA

[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55417 USA

[4] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA

来源：

NEUROLOGY | 1998年 / 50卷 / 06期

关键词：

D O I：

10.1212/WNL.50.6.1900

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76 +/- 10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.

引用

页码：1900 / 1902

页数：3

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