Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues

被引:25
作者
Mohri, Yasuaki
Umezu, Tomohiro [2 ,3 ]
Hidema, Shizu
Tomisawa, Hayato
Akamatsu, Atsushi
Kato, Shigeki
Nawa, Akihiro [4 ]
Nishimori, Katsuhiko [1 ]
机构
[1] Tohoku Univ, Grad Sch Agr Sci, Mol Biol Lab, Aoba Ku, Sendai, Miyagi 9818555, Japan
[2] Tokyo Univ Sci, Dept Biol Sci & Technol, Chiba, Japan
[3] Tokyo Univ Sci, Tissue Engn Res Ctr, Chiba, Japan
[4] Nagoya Univ, Grad Sch Med, Dept Obstet & Gynecol, Nagoya, Aichi 4648601, Japan
基金
日本学术振兴会;
关键词
Lgr4; K5-Cre-transgenic mice; reproductive tract; OVIDUCTAL FLUID GLYCOPROTEIN; POSTNATAL-DEVELOPMENT; OVARIAN-FOLLICLE; DOWN-REGULATION; MOUSE; EXPRESSION; GENE; KNOCKOUT; GPR48;
D O I
10.1016/j.fertnstert.2010.05.050
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Lgr4 is one of the genes identified as novel G protein-coupled receptor genes designated Lgr4-Lgr8, with high homology with FSH receptor, LH receptor, and TSH receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has essential functions in development. This is the first report describing the relationship between the functions of Lgr4 and female reproductive systems. (Fertil Steril (R) 2010;94:2878-81. (C) 2010 by American Society for Reproductive Medicine.)
引用
收藏
页码:2878 / 2881
页数:4
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