Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome

被引：39

作者：

Ring, HZ

Vameghi-Meyers, V

Wang, WD

Crabtree, GR

Francke, U ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

来源：

GENOMICS | 1998年 / 51卷 / 01期

关键词：

D O I：

10.1006/geno.1998.5343

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components of human SWZ/SNF-like chromatin-remodeling protein complexes. We mapped five human SMARC genes to regions on four different human chromosomes, SMARCC1 to 3p23-p21, SMARCC2 to 12q13-q14, SMARCD1 to 12q13-q14, SMARCD2 to 17q23-q24, and SMARCD3 to 7q35-q36. SMARCC1, SMARCC2, and SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers. SMARCD1 was mapped to the critical region of Allgrove syndrome; however, no mutation was identified in one Allgrove syndrome family studied. (C) 1998 Academic Press.

引用

页码：140 / 143

页数：4

共 19 条

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