GABAB-receptor isoforms -: Molecular architecture and distribution

被引：26

作者：

Möhler, H

Benke, D

Fritschy, JM

机构：

[1] Swiss Fed Inst Technol, Inst Pharmacol, CH-8057 Zurich, Switzerland

[2] Univ Zurich, CH-8057 Zurich, Switzerland

来源：

LIFE SCIENCES | 2001年 / 68卷 / 19-20期

关键词：

GABA(B)-receptor subtype; GABA(B)-receptor expression; immunohistochemistry;

D O I：

10.1016/S0024-3205(01)01018-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The slow component of GABAergic inhibition in the brain is mediated by the metabotropic GABA(B)-receptors. Most if not all GABA(B)-receptors are heterodimers of GABA(B)R1 (GBR1) and GABA(B)R2 (GBR2) proteins. Distinctive receptor isoforms are based on the presence of two GBR1 splice variants termed GBR1a and GBR1b. Both were found to be associated with GBR2 suggesting that the isoforms GBR1a/GBR2 and GBR1b/GBR2 represent the vast majority of GABA(B)-receptors in the brain. The two isoforms differed strikingly in their pattern of expression on the regional, cellular and subcellular level. These results point to distinct funcional roles of the two receptor isoforms. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：2297 / 2300

页数：4

共 11 条

[1] γ-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distribution [J].