Current status and progress in gastric cancer with liver metastasis

被引：31

作者：

Liu Jing ^{[1
,2
]}

Chen Lin ^{[1
,2
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, Beijing 100853, Peoples R China

[2] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2011年 / 124卷 / 03期

基金：

中国国家自然科学基金;

关键词：

gastric cancer; liver metastasis; diagnostic imaging; therapeutics; RADIOFREQUENCY ABLATION; HEPATIC RESECTION; PALLIATIVE GASTRECTOMY; PROGNOSTIC-FACTORS; E-CADHERIN; PHASE-III; CURATIVE RESECTION; ARTERIAL INFUSION; SURVIVAL BENEFIT; F-18-FDG PET;

D O I：

10.3760/cma.j.issn.0366-6999.2011.03.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective This review discusses the current status and progress in studies on gastric cancer with liver metastasis (GCLM), involving the routes, subtypes, and prognosis of GCLM; the genes and molecules associated with metastasis; the feasibility and value of each imaging modality; and current treatment options. Data sources The data used in this review were mainly from Medline and PubMed published in English from 2005 to August 2010. The search terms were "gastric cancer" and "liver metastasis". Study selection Articles regarding the characteristics, diagnostic modalities, and various therapeutic options of GCLM were selected. Results The prognosis of GCLM is influenced by the clinicopathological characteristics of primary tumors, as well as the presence of liver metastases. Improved understanding of related genes and molecules will lead to the development of methods of early detection and targeted therapies. For the diagnosis of GCLM, each imaging modality has its relative benefits. There remains no consensus regarding therapeutic options. Conclusions Early detection and characterization of liver metastases is crucial for the prognosis of gastric cancer patients. Multidisciplinary team discussions are required to design optimal treatment strategies, which should be based on the clinicopathological characteristics of each patient. Chin Med J 2011;124(3):445-456

引用

页码：445 / 456

页数：12

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