Mechanisms of leukocyte lipid body formation and function in inflammation

被引:38
作者
Bozza, PT [1 ]
Bandeira-Melo, C [1 ]
机构
[1] Fiocruz MS, Inst Oswaldo Cruz, Dept Fisiol & Farmacodinam, Lab Imunofarmacol, BR-21040900 Rio De Janeiro, Brazil
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2005年 / 100卷
关键词
inflammation; lipid bodies; eicosanoids;
D O I
10.1590/S0074-02762005000900020
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
An area of increasingly interest for the understanding of cell signaling are the spatio-temporal aspects of the different enzymes involved in lipid mediator generation (eicosanoid-forming enzymes, phospholipases and their regulatory kinases and phosphatases) and pools of lipid precursors. The compartmentalization of signaling components within discrete and dynamic sites in the cell is critical for specificity and efficiency of enzymatic reactions of phosphorilation, enzyme activation and function. We hypothesized that lipid bodies - inducible non-membrane bound cytoplasmic lipid domains - function as specialized intracellular sites of compartmentalization of signaling with major roles in lipid mediator formation within leukocytes engaged in inflammatory process. Over the past years substantial progresses have been made demonstrating that all enzymes involved in eicosanoid synthesis localize at lipid bodies and lipid bodies are distinct sites for eicosanoid generation. Here we will review our current knowledge on the mechanisms of formation and functions of lipid bodies pertinent to inflammation.
引用
收藏
页码:113 / 120
页数:8
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