Monoclonal antibody to parathyroid hormone-related protein induces differentiation and apoptosis of chondrosarcoma cells

被引：16

作者：

Miyaji, T

Nakase, T

Onuma, E

Sato, K

Myoui, A

Tomita, T

Joyama, S

Ariga, K

Hashimoto, J

Ueda, T

Yoshikawa, H

机构：

[1] Osaka Univ, Sch Med, Dept Orthopaed Surg, Suita, Osaka 5650871, Japan

[2] Chugai Pharmaceut Co Ltd, Fuji Gotemba Res Labs, Senior Researcher Pharmaceut Res Lab 2, Shizuoka 4128513, Japan

来源：

CANCER LETTERS | 2003年 / 199卷 / 02期

关键词：

apoptosis; chondrosarcoma; anti-PTHrP MoAb; PTHrP; differentiation;

D O I：

10.1016/S0304-3835(03)00347-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the effects of treatment with anti-parathyroid hormone-related protein (1-34) monoclonal murine antibody (anti-PTHrP MoAb) on apoptosis and the differentiation of chondrosarcoma HTB-94 cells. Treatment with anti-PTHrP MoAb accelerated apoptosis of HTB-94 cells in a dose-dependent manner, and anti-PTHrP MoAb also promoted the chondrogenic differentiation of HTB-94 cells. The induction of apoptosis by anti-PTHrP MoAb via imbalance of Bcl-2/Bax ratio and activation of caspase-3 may provide a mechanistic explanation for its potential antitumor effects. Our results suggest the possibility that anti-PTHrP MoAb may be beneficial as a new treatment for chondrosarcoma. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：147 / 155

页数：9

共 28 条

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