Molecular dimensions of gastrointestinal tumors: Some thoughts for digestion

被引：16

作者：

Cohen, MM ^{[1
]}

机构：

[1] Dalhousie Univ, Dept Oral & Maxillofacial Surg, Halifax, NS B3H 3J5, Canada

[2] Dalhousie Univ, Dept Pediat, Halifax, NS B3H 3J5, Canada

[3] Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS B3H 3J5, Canada

[4] Dalhousie Univ, Dept Hlth Serv Adm, Halifax, NS B3H 3J5, Canada

[5] Dalhousie Univ, Dept Sociol & Social Anthropol, Halifax, NS B3H 3J5, Canada

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART A | 2003年 / 122A卷 / 04期

关键词：

neoplasms; polyposis; colorectal cancer; gastrointestinal stromal tumors; PTEN hamartoma-tumor syndrome; WNT; APC; beta-catenin; mismatch-repair genes; MLH1; MSH2; PMS1; MSH6; MYH; STK11; Peutz-Jeghers syndrome; TGF beta; SMADs; BMPR1A; FGF/FGFR; PTCH; RUNX3; mucins; MUC1; KIT; PDGFR alpha; intestinal neurofibromatosis;

D O I：

10.1002/ajmg.a.20473

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary non-polyposis colorectal cancer; MYH mutations and autosomal recessive colorectal tumors; STK11 mutations and Peutz-Jeghers syndrome; TGFbeta and gastrointestinal cancer; BMPR1A mutations and juvenile polyposis; FGF/FGFR alterations in gastrointestinal neoplasms; PTCH mutations and gastrointestinal neoplasms; RUNX3 expression and gastric cancer; role of mucins in gastric carcinogenesis; KIT, PDGFRalpha, and gastrointestinal stromal tumors; intestinal neurofibromatosis; and gastrointestinal tumors in other disorders. (C) 2003 Wiley-Liss, Inc.

引用

页码：303 / 314

页数：12

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