Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis

被引：22

作者：

de Bustos, F

Jiménez-Jiménez, FJ

Molina, JA

Esteban, J

Guerrero-Sola, A

Zurdo, M

Ortí-Pareja, M

Tallón-Barranco, A

Gómez-Escalonilla, C

Ramírez-Ramos, C

Arenas, J

de Salamanca, RE

机构：

[1] Hosp 12 Octubre, Dept Biochem, E-28041 Madrid, Spain

[2] Hosp 12 Octubre, Dept Neurol, E-28041 Madrid, Spain

[3] Univ Alcala de Henares, Hosp Principe de Asturias, Neurol Sect, Alcala De Henares, Spain

[4] Hosp Univ San Carlos, Serv Neurol, Madrid, Spain

[5] Univ Complutense Madrid, Dept Med, Madrid, Spain

来源：

JOURNAL OF NEURAL TRANSMISSION | 1998年 / 105卷 / 6-7期

关键词：

amyotrophic lateral sclerosis; motoneuron disease; alpha-tocopherol; vitamin E; cerebrospinal fluid levels; serum levels;

D O I：

10.1007/s007020050089

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 30 patients with sporadic amyotrophic lateral sclerosis (SALS) and 78 matched controls. The mean CSF and serum vitamin E levels did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal versus bulbar) of SALS. CSF alpha-tocopherol levels did not correlate with age, age at onset, and duration of the disease. These results suggest that CSF and serum alpha-tocopherol concentrations are unrelated with the risk for ALS.

引用

页码：703 / 708

页数：6

共 30 条

[1] OXIDATIVE STRESS - ITS ROLE IN THE PATHOGENESIS OF AMYOTROPHIC-LATERAL-SCLEROSIS [J].