The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21

被引：286

作者：

Cariappa, A

Tang, M

Parng, C

Nebelitskiy, E

Carroll, M

Georgopoulos, K

Pillai, S ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA

[2] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Boston, MA 02129 USA

[3] Harvard Univ, Sch Med, Boston, MA 02129 USA

[4] Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA

来源：

IMMUNITY | 2001年 / 14卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(01)00135-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most splenic B cells in mice that lack Aiolos are mature IgD(hi)IgM(lo) follicular lymphocytes, suggesting that maturation signals delivered via the BCR are enhanced in the absence of Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which depend on the generation of signals via Btk, which is in epistasis to Aiolos. The inverse relationship between the strength of BCR signaling and MZ B cell development is supported by an examination of MZ B cells in CD21 null mice. These data support the view that antigens tin contrast to "tonic" signals) drive the development of naive B cells.

引用

页码：603 / 615

页数：13

共 45 条

[1] Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen [J].