DNA repair: How to PIKK a partner

被引：21

作者：

Hiom, K ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Prot & Nucle Acid Chem Div, Cambridge CB2 2QH, England

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 12期

关键词：

D O I：

10.1016/j.cub.2005.06.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotes, members of the phosphoinositide-3-kinase-related protein kinase (PIKK) family co-ordinate the cellular response to DNA damage. But how do these important kinases detect DNA damage and relay this information to the DNA repair and checkpoint machinery?.

引用

页码：R473 / R475

页数：3

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