Towards systematic functional characterization of cancer genomes

被引：66

作者：

Boehm, Jesse S. ^{[1
]}

Hahn, William C. ^{[1
,2
,3
,4
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Dana Farber Canc Inst, Ctr Canc Genome Discovery, Dept Med Oncol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 07期

基金：

美国国家卫生研究院;

关键词：

RNA INTERFERENCE SCREEN; LOSS-OF-FUNCTION; SYNTHETIC LETHAL INTERACTIONS; CELL LUNG-CANCER; NF-KAPPA-B; GENETIC SCREEN; BREAST-CANCER; KINASE REQUIREMENTS; SMALL-MOLECULE; LIVER-CANCER;

D O I：

10.1038/nrg3013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Whole-genome approaches to identify genetic and epigenetic alterations in cancer genomes have begun to provide new insights into the range of molecular events that occurs in human tumours. Although in some cases this knowledge immediately illuminates a path towards diagnostic or therapeutic implementation, the bewildering lists of mutations in each tumour make it clear that systematic functional approaches are also necessary to obtain a comprehensive molecular understanding of cancer. Here we review the current range of methods, assays and approaches for genome-scale interrogation of gene function in cancer. We also discuss the integration of functional-genomics approaches with the outputs from cancer genome sequencing efforts.

引用

页码：487 / 498

页数：12

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