Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques

被引：16

作者：

Kent, Stephen J. ^{[1
]}

De Rose, Robert ^{[1
]}

Mokhonov, Vlad V. ^{[4
]}

Mokhonova, Ekaterina I. ^{[4
]}

Fernandez, Caroline S. ^{[1
]}

Alcantara, Sheilajen ^{[1
]}

Rollman, Erik ^{[1
]}

Mason, Rosemarie D. ^{[1
]}

Loh, Liyen ^{[1
]}

Peut, Viv ^{[1
]}

Reece, Jeanette C. ^{[1
]}

Wang, Xiang Ju ^{[4
]}

Wilson, Kim M. ^{[2
]}

Suhrbier, Andreas ^{[3
]}

Khromykh, Alexander ^{[4
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

[2] Natl Serol Reference Lab, Fitzroy, Vic 3065, Australia

[3] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[4] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia

来源：

VIROLOGY | 2008年 / 374卷 / 02期

基金：

英国医学研究理事会;

关键词：

Kunjin; HIV; SIV; macaques; Macaca nemestrina; vaccines;

D O I：

10.1016/j.virol.2008.01.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Persistent gag-specific T cell immunity would be a useful component of an effective HIV vaccine. The Flavivirus Kunjin replicon was previously engineered to persistently express HIV gag and was shown to induce protective responses in mice. We evaluated Kunjin replicon virus-like-particles expressing SIVgag-pol in pigtail macaques. Kunjin-specific antibodies were induced, but no SIV-specific T cell immunity were detected. Following SIVmac251 challenge, there was no difference in SIV viremia or retention of CD4 T cells between Kunjin-SIVgag-pol vaccine immunized animals and controls. An amnestic SIV gag-specific CD8 T cell response associated with control of viremia was observed in 1 of 6 immunized animals. Refinements of this vector system and optimization of the immunization doses, routes, and schedules are required prior to clinical trials. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：528 / 534

页数：7

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