Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

被引：80

作者：

Crowe, Francesca L. ^{[1
]}

Key, Timothy J. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Travis, Ruth C. ^{[1
]}

Overvad, Kim ^{[2
]}

Jakobsen, Marianne U. ^{[2
]}

Johnsen, Nina F. ^{[3
]}

Tjonneland, Anne ^{[3
]}

Linseisen, Jakob ^{[4
]}

Rohrmann, Sabine ^{[4
]}

Boeing, Heiner ^{[5
]}

Pischon, Tobias ^{[5
]}

Trichopoulou, Antonia ^{[6
]}

Lagiou, Pagona ^{[6
]}

Trichopoulos, Dimitrios ^{[7
,8
]}

Sacerdote, Carlotta ^{[9
]}

Palli, Domenico ^{[10
]}

Tumino, Rosario ^{[11
]}

Krogh, Vitorrio ^{[12
]}

Bueno-de-Mesquita, H. Bas ^{[13
]}

Kiemeney, Lambertus A. ^{[14
]}

Chirlaque, Maria-Dolores ^{[15
]}

Ardanaz, Eva ^{[16
]}

Sanchez, Maria-Jose ^{[16
,17
]}

Larranaga, Nerea ^{[18
]}

Gonzalez, Carlos A. ^{[19
]}

Quiros, Jose R. ^{[20
]}

Manjer, Jonas ^{[21
]}

Wirfalt, Elisabet ^{[22
]}

Stattin, Par ^{[23
]}

Hallmans, Goran ^{[24
]}

Khaw, Kay-Tee ^{[25
]}

Bingham, Sheila ^{[26
,27
]}

Ferrari, Pietro ^{[28
]}

Slimani, Nadia ^{[28
]}

Jenab, Mazda ^{[28
]}

Riboli, Elio ^{[29
]}

机构：

[1] Univ Oxford, Canc Res UK Epidemiol Unit, Oxford OX3 7LF, England

[2] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[3] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[4] German Canc Res Ctr, Div Canc Epidemiol, Unit Nutr Epidemiol, D-6900 Heidelberg, Germany

[5] German Inst Human Nutr, Potsdam, Germany

[6] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Hellen Hlth Fdn, Athens, Greece

[9] Epidemiol & Prevenz Oncol CPO Piemonte, Turin, Italy

[10] CSPO Sci Inst Tuscany, Mol & Nutr Epidemiol Unit, Florence, Italy

[11] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[12] Natl Canc Inst, Nutr Epidemiol Unit, Dept Prevent & Prevent Med, I-20133 Milan, Italy

[13] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, NL-3720 BA Bilthoven, Netherlands

[14] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[15] Murcia Hlth Council, Dept Epidemiol, Pamplona, Spain

[16] Publ Hlth Inst Navarra, Pamplona, Spain

[17] Andalusian Sch Publ Hlth, Granada, Spain

[18] Basque Govt, Publ Hlth Dept Gipuzkoa, Donostia San Sebastian, Spain

[19] Catalan Inst Oncol, Dept Epidemiol, Barcelona, Spain

[20] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[21] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[22] Lund Univ, Dept Clin Sci Malmo Nutr Epidemiol, Malmo, Sweden

[23] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[24] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[25] Univ Cambridge, Dept Gerontol, Cambridge, England

[26] Univ Cambridge, MRC, Dunn Human Nutr Unit, Cambridge, England

[27] Univ Cambridge, Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, MRC, Cambridge, England

[28] Int Agcy Res Canc, Nutr & Hormones Grp, F-69372 Lyon, France

[29] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2008年 / 87卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1093/ajcn/87.5.1405

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.

引用

页码：1405 / 1413

页数：9

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