Bruton's Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cell Malignancies

被引：78

作者：

Lou, Yan ^{[1
]}

Owens, Timothy D. ^{[1
]}

Kuglstatter, Andreas ^{[1
]}

Kondru, Rama K. ^{[1
]}

Goldstein, David M. ^{[1
]}

机构：

[1] Hoffmann La Roche Inc, Discovery Chem, Small Mol Res, pRED,Pharma Res & Early Dev, Nutley, NJ 07110 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 10期

关键词：

X-LINKED AGAMMAGLOBULINEMIA; CRYSTAL-STRUCTURES; DRUG DESIGN; SRC FAMILY; BTK; ACTIVATION; ARTHRITIS; DASATINIB; MECHANISM; INSIGHTS;

D O I：

10.1021/jm300035p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：4539 / 4550

页数：12

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