Growing roles for the mTOR pathway

被引：1348

作者：

Sarbassov, DD ^{[1
]}

Ali, SM ^{[1
]}

Sabatini, DM ^{[1
]}

机构：

[1] MIT, Dept Biol, Whitehead Inst, Cambridge, MA 02142 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ceb.2005.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian TOR (mTOR) pathway is a key regulator of cell growth and proliferation and increasing evidence suggests that its deregulation is associated with human diseases, including cancer and diabetes. The mTOR pathway integrates signals from nutrients, energy status and growth factors to regulate many processes, including autophagy, ribosome biogenesis and metabolism. Recent work identifying two structurally and functionally distinct mTOR-containing multiprotein complexes and TSC1/2, rheb, and AMPK as upstream regulators of mTOR is beginning to reveal how mTOR can sense diverse signals and produce a myriad of responses.

引用

页码：596 / 603

页数：8

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