Anti-IgE therapy

被引：28

作者：

Brownell, J ^{[1
]}

Casale, TB ^{[1
]}

机构：

[1] Creighton Univ, Sch Med, Dept Med, Div Allergy & Immunol, Omaha, NE 68131 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2004年 / 24卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.iac.2004.06.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 [免疫学];

摘要：

IgE has a central role in the initiation of allergic hypersensitivity reactions. Pioneered by the development of humanized monoclonal antibodies directed against IgE, anti-IgE therapy represents an original approach to the treatment of allergic disease and has demonstrated promise in preventing the symptoms of asthma, allergic rhinitis, and food allergy. The primary mechanism of action of anti-IgE therapy is the reduction in serum levels of IgE and FcEεRI expression on mast cells and basophils.

引用

页码：551 / +

页数：19

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