Natalizumab Drug Holiday in Multiple Sclerosis: Poorly Tolerated

被引：101

作者：

Killestein, Joep ^{[1
]}

Vennegoor, Anke ^{[1
]}

Strijbis, Eva M. ^{[1
]}

Seewann, Alexandra ^{[1
]}

van Oosten, Bob W. ^{[1
]}

Uitdehaag, Bernard M. J. ^{[1
,2
]}

Polman, Chris H. ^{[1
]}

机构：

[1] MS Ctr Amsterdam, Dept Neurol, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 03期

关键词：

JC VIRUS; REACTIVATION; BLOOD; URINE;

D O I：

10.1002/ana.22074

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been suggested that natalizumab-associated progressive multifocal leukoencephalopathy may be prevented by structured interruptions of treatment. Evidence supporting such a drug holiday is not yet available. Here we present initial observations in 10 multiple sclerosis patients who were stringently monitored up to 6 months after discontinuation of the infusions. Cumulatively, a combination of clinical relapse and new and/or enhanced lesions on magnetic resonance imaging had occurred in 7 of 10 patients. Although numbers are small, our data suggest that in patients who were switched to natalizumab because of disease activity despite first-line treatment, a natalizumab drug holiday without reinstatement of alternate disease-modifying therapy is poorly tolerated. ANN NEUROL 2010;68:392-395

引用

页码：392 / 395

页数：4

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