Metabolic control of proteasome function

被引：30

作者：

Zhang, Fengxue ^{[3
]}

Paterson, Andrew J. ^{[1
,3
]}

Huang, Ping ^{[2
]}

Wang, Kai ^{[1
]}

Kudlow, Jeffrey E. ^{[1
,3
]}

机构：

[1] Univ Alabama Birmingham, Dept Physiol Biophys, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Pharmacol & Toxicol, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Med, Div Endocrinol Diabet & Metab, Birmingham, AL USA

来源：

PHYSIOLOGY | 2007年 / 22卷 / 06期

关键词：

D O I：

10.1152/physiol.00026.2007

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Proteasomes are major cellular proteases that are important for protein turnover and cell survival. Dysregulation of proteasome is related to many major human diseases. Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation.

引用

页码：373 / 379

页数：7

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