A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster

被引：89

作者：

Lorén, CE

Englund, C

Grabbe, C

Hallberg, B

Hunter, T

Palmer, RH

机构：

[1] Umea Univ, Umea Ctr Mol Pathogenesis, S-90187 Umea, Sweden

[2] Umea Univ, Dept Pathol, S-90187 Umea, Sweden

[3] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA

来源：

EMBO REPORTS | 2003年 / 4卷 / 08期

关键词：

D O I：

10.1038/sj.embor.embor897

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, which encodes a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans, the t(2; 5) translocation, which involves the ALK locus, produces an active form of ALK, which is the causative agent in non-Hodgkin's lymphoma. The physiological function of the Alk RTK, however, is unknown. In this paper, we describe loss-of-function mutants in the Drosophila Alk gene that cause a complete failure of the development of the gut. We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development.

引用

页码：781 / 786

页数：6

共 23 条

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