Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

被引：1408

作者：

Liu, Yingxia ^{[1
]}

Yang, Yang ^{[1
,2
,3
]}

Zhang, Cong ^{[4
]}

Huang, Fengming ^{[4
]}

Wang, Fuxiang ^{[1
]}

Yuan, Jing ^{[1
]}

Wang, Zhaoqin ^{[1
]}

Li, Jinxiu ^{[1
]}

Li, Jianming ^{[1
]}

Feng, Cheng ^{[1
]}

Zhang, Zheng ^{[1
]}

Wang, Lifei ^{[1
]}

Peng, Ling ^{[1
]}

Chen, Li ^{[1
]}

Qin, Yuhao ^{[4
]}

Zhao, Dandan ^{[4
]}

Tan, Shuguang ^{[5
]}

Yin, Lu ^{[6
]}

Xu, Jun ^{[6
]}

Zhou, Congzhao ^{[2
,3
]}

Jiang, Chengyu ^{[4
]}

Liu, Lei ^{[1
]}

机构：

[1] Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, State Key Discipline Infect Dis,Shenzhen Peoples, Natl Clin Res Ctr Infect Dis,Hosp Affiliated 1, Shenzhen 518112, Peoples R China

[2] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China

[4] Chinese Acad Med Sci, Dept Biochem, Peking Union Med Coll, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China

[5] Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China

[6] Peking Union Med Coll Hosp, Emergence Dept, Beijing 100731, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2020年 / 63卷 / 03期

基金：

中国博士后科学基金;

关键词：

2019-nCoV; Angiotensin II; ARDS; ANGIOTENSIN-CONVERTING ENZYME-2; CORONAVIRUS; INHIBITORS; PEPTIDES; PROTECTS; RISK;

D O I：

10.1007/s11427-020-1643-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

引用

页码：364 / 374

页数：11

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