Post-transcriptional gene silencing by double-stranded RNA

被引：673

作者：

Hammond, SM

Caudy, AA

Hannon, GJ

机构：

[1] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] Genetica Inc, Cambridge, MA 01239 USA

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 02期

关键词：

D O I：

10.1038/35052556

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Imagine being able to knock out your favourite gene with only a day's work. Not just in, one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing of homologous endogenous genes. How this phenomenon works is slowly becoming clear, and might help us to develop an effortless tool to probe gene function in cells and animals.

引用

收藏

页码：110 / 119

页数：10

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