Expeditious preparation of 2-substituted quinolines

被引：49

作者：

Fakhfakh, MA

Franck, X

Fournet, A

Hocquemiller, R

Figadère, B

机构：

[1] Univ Paris Sud, Fac Pharm, Associe CNRS BIOCIS, Lab Pharmacognosie, F-92296 Chatenay Malabry, France

[2] IRD, F-75480 Paris, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 23期

关键词：

quinolines; Grignard reagents; multi-components reaction;

D O I：

10.1016/S0040-4039(01)00604-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of 2-substituted quinolines was synthesized in solution from mixtures of Grignard reagents and a quinolinium salt. Grignard reagents were prepared in one pot, taking advantage of the entrainment method for their preparation from unreactive alkyl halides. Then mixtures of 2-alkylquinolines were readily accessible for biological tests or separated by centrifugal-partition chromatography (CPC) prior to the biological screening. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3847 / 3850

页数：4

共 21 条

[1] THE REACTION OF BENZYLMAGNESIUM CHLORIDE AND DIBENZYLMAGNESIUM WITH PYRIDINE
BENKESER, RA
HOLTON, DS
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (12) : 5861 - 5862
[2] Dreux M., 1996, LC GC INTERNATIONAL, V9, P148
[3] CHEMISTRY OF DIHYDROPYRIDINES
EISNER, U
KUTHAN, J
[J]. CHEMICAL REVIEWS, 1972, 72 (01) : 1 - +
[4] REGIOSELECTIVE CYANATION OF PYRIDINE 1-OXIDES WITH TRIMETHYLSILANECARBONITRILE - A MODIFIED REISSERT-HENZE REACTION
FIFE, WK
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (08) : 1375 - 1377
[5] FOUCAULT AP, 1995, CPC CHROMATOGRAPHY S, V68
[6] CHIMANINES, NEW 2-SUBSTITUTED QUINOLINES, ISOLATED FROM AN ANTIPARASITIC PLANT IN BOLIVIA - GALIPEA-LONGIFLORA
FOURNET, A
HOCQUEMILLER, R
ROBLOT, F
CAVE, A
RICHOMME, P
BRUNETON, J
[J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (09): : 1547 - 1552
[7] In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis
Fournet, A
Ferreira, ME
deArias, AR
deOrtiz, ST
Fuentes, S
Nakayama, H
Schinini, A
Hocquemiller, R
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (11) : 2447 - 2451
[8] 2-SUBSTITUTED QUINOLINE ALKALOIDS AS POTENTIAL ANTILEISHMANIAL DRUGS
FOURNET, A
BARRIOS, AA
MUNOZ, V
HOCQUEMILLER, R
CAVE, A
BRUNETON, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) : 859 - 863
[9] FRANKEL G, 1970, ANGEW CHEM INT EDIT, V9, P523
[10] The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice
Gantier, JC
Fournet, A
Munos, MH
Hocquemiller, R
[J]. PLANTA MEDICA, 1996, 62 (03) : 285 - 286

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