The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation

被引：63

作者：

Carrizzo, Albino ^{[1
]}

Izzo, Carmine ^{[2
]}

Oliveti, Marco ^{[2
]}

Alfano, Antonia ^{[3
]}

Virtuoso, Nicola ^{[4
]}

Capunzo, Mario ^{[2
]}

Di Pietro, Paola ^{[2
]}

Calabrese, Mariaconsiglia ^{[5
]}

De Simone, Eros ^{[3
]}

Sciarretta, Sebastiano ^{[1
,6
]}

Frati, Giacomo ^{[1
,6
]}

Migliarino, Serena ^{[7
]}

Damato, Antonio ^{[1
]}

Ambrosio, Mariateresa ^{[1
]}

De Caro, Francesco ^{[2
]}

Vecchione, Carmine ^{[1
,2
]}

机构：

[1] IRCCS Neuromed, I-86077 Pozzilli, IS, Italy

[2] Univ Salerno, Dept Med & Surg, I-84081 Baronissi, SA, Italy

[3] AOU San Giovanni di Dio & Ruggi dAragona, Heart Dept, I-84131 Salerno, Italy

[4] AOU Federico II, Dept Cardiovasc Med, I-80131 Naples, Italy

[5] AOU San Giovanni di Dio & Ruggi dAragona, Rehabil Dept, I-84131 Salerno, Italy

[6] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-00161 Rome, Italy

[7] Sapienza Univ Rome, Sch Med & Psychol, Dept Clin & Mol Med, I-00161 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 10期

关键词：

diabetes; endothelial dysfunction; platelets activation; molecular mechanisms; GLYCATION END-PRODUCTS; ADVANCED PROTEIN GLYCOSYLATION; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHESIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; CARDIOVASCULAR EVENTS; ASPIRIN RESISTANCE; IN-VIVO; PLASMINOGEN-ACTIVATOR;

D O I：

10.3390/ijms19102968

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Diabetes mellitus is a common disease that affects 3-5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6-8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

引用

页数：19

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